How to expel a bad tenant: Linking cyclin A2, enucleation and cell size

How to Perform a Standing Enucleation

Enucleation is one of the most frequently performed orbital surgeries. Indications for enucleation include a blind, painful eye; ocular neoplasia; severe corneal or intra-ocular infection; and ocular trauma not amenable to surgical repair. Several publications recommend that equine enucleation only be performed under general anesthesia. However, per several recent reports, enucleation can be pe...

Down-regulation of SOSTDC1 promotes thyroid cancer cell proliferation via regulating cyclin A2 and cyclin E2.

Sclerostin domain containing protein 1 (SOSTDC1) is down-regulated and acts as a tumor suppressor in some kinds of cancers. However, the expression pattern and biological significance of SOSTDC1 in thyroid cancer are largely unknown. We demonstrated that SOSTDC1 was significantly down-regulated in thyroid cancer. Ectopic over-expression of SOSTDC1 inhibited proliferation and induced G1/S arrest...

Exendin-4 Stimulation of Cyclin A2 in β-Cell Proliferation

OBJECTIVE Beta-cell proliferation is an important mechanism underlying beta-cell mass adaptation to metabolic demands. We have examined effects, in particular those mediated through intracellular cAMP signaling, of the incretin hormone analog exendin-4 on cell cycle regulation in beta-cells. RESEARCH DESIGN AND METHODS Changes in islet protein levels of cyclins and of two critical cell cycle ...

How to give a bad talk

Over the years, I’ve listened to hundreds of scientific presentations, often given by brilliant scientists. A few were memorable; many were dull. Unfortunately, being an expert in your field is no guarantee that you will be an effective presenter. But the good news is that it’s probably easier to learn to be an effective speaker than it is to become a brilliant scientist. And, although presenta...

How to give a bad talk